Навчальний посібник з біологічної та біоорганічної хімії для самостійного навчання студентів, містить коротке пояснення всіх розділів дисциплін, відповідає на основні контрольні питання відповідно до Типової програми Міністерства охорони здоров’я України. Ця книга допоможе в орієнтації у великому обсязі матеріалу не тільки студентам 1-го і 2-го курсів, які вивчають біоорганічну та біохімічну хімію, але і студентам 3-го та 4-го курсів для підготовки до ліцензійного іспиту “Crock-1”. Книга написана для студентів вищих медичних закладів III-IV рівнів акредитації.
The teaching textbook in the Biological and Bioorganic Chemistry for the students self-study contains the short explanation of all discipline chapters, answers the key control questions in the accordance to the Typ- ical Program of the Ukraine health Ministry. This book will help in the orientation in the big volume of material not only to students of the 1-st and 2-nd course both, which study Bioorganic and Biochemical Chemis- try, but to the students of 3-rd and 4-th course for the preparation to the license exam “Crock-1”. The book is written for the students of the High Medical School of the III – IY levels of accreditation.
contents
Section I. Biologically important classes of bioorganic compounds.
Biopolymers and their structural components................7
Chapter 1. Theoretical basis of the structure and reactivity
of bioorganic compounds. .................................................7
1.1. Classification, nomenclature and isomerism of bioorganic
compounds. The nature of chemical bonds. ..................................7
1.2. Classification of chemical reactions. Reactivity of alkanes,
alkenes, arenes, alcohols, phenols, amines..................................14
1.3. Structure and properties of aldehydes and ketones......................19
1.4. Oxidation of aldehydes and ketones............................................22
1.4. Structure, properties and biological significance of carboxylic
acids.............................................................................................24
Chapter 2. Higher fatty acids. Lipids. Phospholipids. α-amino acids,
peptides, proteins..............................................................27
2.1. Higher fatty acids. Lipids. Phospholipids....................................27
2.2. Amino acid composition of proteins and peptides.......................31
2.3. Structural organization of proteins. Physico-chemical properties
of proteins. Reactions deposition of proteins. Denaturation Levels
of the structure of protein molecules. ..........................................40
Chapter 3. Carbohydrates. Monosaccharides. Oligo-and
polysaccharides................................................................45
3.1. Carbohydrates. The structure and chemical properties of
monosaccharides..........................................................................45
Chapter 4. Biologically active heterocyclic compounds. Nucleosides,
nucleotides, nucleic acids ................................................52
4.1. Classification, structure and significance of heterocyclic
compounds...................................................................................52
4.2. Structure and biochemical functions of nucleosides and
nucleotides...................................................................................60
4.3. Structure and biological role of nucleic acids..............................61
Section II. The general pattern of metabolism...............................65
Chapter 5. The biochemical components of cells. ............................65
4
Chapter 6. Enzymes and coenzymes, coenzyme function of vitamins.
Regulation of metabolism................................................68
6.1. Enzymes. Structure, physico-chemical properties of proteins,
enzymes, classified by type of reaction .......................................68
6.2. Mechanism of action and determination of enzyme activity.......70
6.3. Kinetics of enzymatic catalysis. Enzyme inhibitors....................70
6.4. Cofactors and coenzymes. Coenzyme functions of vitamins ......72
Chapter 7. Basic laws of metabolism Citric acid cycle .....................74
7.1. Metabolism. Catabolism, anabolism. The general path of reform
of proteins, carbohydrates, lipids.................................................74
7.2. Citric acid cycle ...........................................................................75
Chapter 8. Molecular Basis of bioenergetics. ...................................77
8.1. Bioenergetics processes: biological oxidation, oxidative
phosphorylation, ATP synthesis...................................................77
8.2. Chemiosmotic theory of oxidative phosphorylation.
Inhibitors and uncouplers of oxidative phosphorylation .............80
8.3. Shuttle transport mechanisms across the membrane
of mitochondria............................................................................86
8.4. The formation of free radicals, peroxides and antioxidants.........90
Section III. Metabolism of carbohydrates, lipids, amino acids
and its regulation...........................................................93
Chapter 9. Carbohydrate metabolism and its regulation..................93
9.1. Metabolism of carbohydrates. Anaerobic oxidation of glucose –
glycolysis and glycogen – glycogenolysis...................................93
9.2. Aerobic oxidation of glucose. Alternative ways of sharing
monosaccharides. The metabolism of fructose and galactose.
Pentose phosphate pathway.........................................................97
9.3. Biosynthesis of glucose – gluconeogenesis and glycogen
biosynthesis. Genetic metabolic glycogen.................................103
Chapter 10. Lipid metabolism and its regulation............................108
10.1. Lipid Metabolism: catabolism of triacyl glycerols,
the regulation of lipolysis. Metabolism of
ketone bodies ...........................................................................108
10.2. The biosynthesis of the active form of higher fatty acids........ 114
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10.3. Biosynthesis and biotransformation of cholesterol, bile acids.
Pathology of lipid metabolism: steatorreya, obesity,
atherosclerosis.......................................................................... 119
Chapter 11. Metabolism of amino acids.
Enzymopathology of amino acid metabolism..............124
11.1. General ways of amino acids transformation...........................125
11.2 Detoxication of ammonia, urea biosynthesis............................129
11.3. Specialized ways of sharing the noncyclic and cyclic amino
acids. The biosynthesis of glutathione and creatine.
Enzymopathology of amino acid metabolism..........................132
Section IV. Molecular Biology. Biochemistry
of intercellular communication...................................141
Chapter 12. Fundamentals of molecular biology ...........................141
12.1. Biochemical functions of nucleotides and nucleic acids .........141
12.2. Biosynthesis and catabolism of purine and pyrimidine
nucleotides. Hereditary metabolic uric acid disturbances........141
12.3. Enzymes and molecular mechanisms of DNA replication.
Transcription – RNA biosynthesis...........................................147
12.4. Protein biosynthesis in ribosomes. Stages and mechanism of
translation, regulation of broadcasting. Antibiotics inhibitors of
transcription and translation.....................................................150
Chapter 13. Basics of molecular genetics.......................................153
13.1. Regulation of gene expression in prokaryotes and eukaryotes 153
13.2. Molecular mechanisms of mutations. DNA reparation............154
Chapter 14. Molecular mechanisms of hormones action
on target cells................................................................155
14.1. Molecular-cellular mechanisms of the hormonal
signal transfer...........................................................................155
Chapter 15. Biochemistry hormonal regulation.............................159
15.1. Hormonal regulation of metabolism and cellular functions: the
hormones of the hypothalamic-pituitary and thyroid gland.
Regulation of calcium homeostasis .........................................159
15.2. Hormones of the pancreas. Regulation of carbohydrate
metabolism...............................................................................166
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15.3. Hormones of adrenal and sex glands. Physiologically active
eicosanoids...............................................................................172
Section V. Biochemistry of tissues
and physiological functions..........................................183
Chapter 16. Biochemistry of human nutrition. Nutrition ..............183
16.1. Mechanisms of digestion of nutrients in the digestive tract ....183
16.2. Vitamins as components of nutrition: exogenous
and endogenous hypovitaminosis............................................187
16.3. Lipid-soluble vitamins, antioxidants........................................196
Chapter 17. Biochemistry and patobiohemistry of blood ...............201
17.1. Biochemical composition of blood in health and disease:
acute phase inflammatory proteins,
enzymes of blood plasma.........................................................201
17.2. Non-proteinaceous nitrogen-containing and nitrogen-free
organic components of blood. Plasma lipoproteins.................203
17.3. The respiratory function of erythrocytes. Acid-base status,
the buffer system of blood .......................................................205
17.4. Coagulant, anticoagulant and fibrtynolytic system of blood ...209
17.5. Biochemistry of immune processes and biochemical
mechanisms of immunodeficiency condition...........................216
Chapter 18. Functional and clinical biochemistry of organs
and tissues.....................................................................218
18.1. Biochemical functions of the liver. Porphyrin metabolism:
the metabolism of bile pigments, Biochemistry of jaundice....218
18.2. Biotransformation of xenobiotics and endogenous toxins
in the liver: microsomal oxidation, cytochrome P-450............223
18.3. Urine production in kidney. Normal and pathological
components of urine.................................................................224
18.4. Biochemistry of muscle, muscle contraction and connective
tissue ........................................................................................229
18.5. Biochemistry of nervous tissue. Pathobiochemistry of mental
disorders...................................................................................235
REFERENCES .................................................................................240
Біологічна і біоорганічна хімія (англ. мовою). Biological and bioorganical chemisrty. Навч. посібник. Рек. МОНУ Мардашко О.О.
- Виробник: Каравела
- Модель: посібник
- Наявність: Є в наявності
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280 грн.
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Біологічна і біоорганічна хімія (англ. мовою). Biological and bioorganical chemisrty. Навч. посібник. Рек. МОНУ Мардашко О.О.